Info

The Pharmacist Answers Podcast

Have a question for the pharmacist? Get your answers here! Clear explanations about complicated medical topics that anyone can understand. Disclaimer: The information contained in this blog and related podcast are not to be taken as medical advice, they are for informational and educational purposes only. If you resemble anything that is mentioned in this blog or related podcast, contact your doctor. The information contained in this blog and related podcasts is the opinion of the author and does not relfect the views of her employer, Walgreens. If you want to know what Walgreens thinks, ask Walgreens!
RSS Feed Subscribe in iTunes
The Pharmacist Answers Podcast
2017
June
May
April
March
February
January


2016
December
November
October
September
August
July
June
May
April
March
February
January


2015
December
November
October
September
August
July


All Episodes
Archives
Now displaying: Page 1
Feb 13, 2017

The blood brain barrier is the last layer of cells between what's in your blood and the extracellular fluid around your brain cells.

You're born with it!  It's main job is filtration...

2 ways things get through the blood brain barrier:
- Passive diffusion: small, neutral molecules (water, gases, lipid-soluble)
- Active transport: glucose, amino acids, drugs (like a revolving door)

Permeability: how easily something can pass through a layer without work

Things that change permeability:
- Inflammation - stretches layer and makes holes bigger (meningitis, injury)
- Multiple sclerosis - an auto-immune disease that can degrade the BBB
- Alzheimer's - BBB becomes overwhelmed with antibodies and burns out

*Scary Section*
Rabies - the virus is small and can get through the blood brain barrier but the immune system cells, antibodies from the vaccine, and medicines can't
HIV encephalopathy - a mutation of HIV can get into the brain and use brain cells to replicate (rather than the well-known T-cells of the immune system).  There is also a rare symptom of HIV called HIV-associated dementia

Pregnancy causes the permeability of many areas of the body to change, and this includes the BBB (callback: microchimerisms)

Drugs that have central nervous system effects (good) or side effects (bad) cross the BBB.

So test yourself - use what you know of different medications and what job they're supposed to do and what negative side effects they cause and see if you can guess if they cross the BBB.

Support us on Patreon

Subscribe: iTunes, Stitcher, GooglePlay, TuneIn Radio

Like the Facebook page

"Radio Martini" Kevin MacLeod (incompetech.com)  Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0/

0 Comments